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Updated: Jun 24, 2026

Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs
Published on: March 9, 2013
PH of medicated syrups--does it really matter?--an in-vitro study: Part-II
K L Girish Babu1, Kavita Rai, Amitha M Hegde
1Department of Pedodontics and Preventive Dentistry, The Oxford Dental College, Hospital and Research Centre, Hosur Road, Bangalore-68, Karnataka, India. drgirish77@yahoo.com
Abstract:
The aim of the present in vitro study was to quantify the endogenous erosive potential of the various pediatric liquid medicaments by measuring the calcium dissolution of primary enamel after immersing it for different time intervals (1 min, 10 min and 8 hours) using atomic absorption spectrometer (AAS). The eight commonly used pediatric liquid medicaments which were selected had definitive endogenous calcium dissolution potential. All the medicaments showed calcium dissolution of primary enamel at alkaline pH and near neutral pH. The calcium dissolution potential of pediatric liquid medicaments when compared with their respective pH showed no statistically significant correlation. In conclusion, there was evidence of calcium dissolution from all the pediatric liquid medicaments.
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