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Total intravenous anaesthesia with propofol or etomidate
K Fruergaard1, M Jenstrup, J Schierbeck
1Department of Anaesthetics, Central Hospital of Hillerød, Denmark.
European Journal of Anaesthesiology
|September 1, 1991
Summary
Propofol and etomidate offer smooth total intravenous anesthesia. Propofol demonstrated faster recovery and fewer side effects, making it advantageous for post-anesthesia care.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Total intravenous anesthesia (TIVA) is a common anesthetic technique.
- Propofol and etomidate are frequently used agents for TIVA.
Purpose of the Study:
- To compare the efficacy and recovery profiles of propofol versus etomidate when used with fentanyl for TIVA.
- To evaluate patient-reported outcomes and side effects in the postoperative period.
Main Methods:
- A randomized study involving 21 women undergoing elective hysterectomy.
- Patients received either propofol or etomidate for TIVA, combined with fentanyl.
- Induction, maintenance, extubation time, and recovery parameters were assessed.
Main Results:
- Both propofol and etomidate provided smooth induction and easy maintenance of anesthesia.
- No significant difference was observed in extubation time between the groups.
- Patients in the propofol group had a significantly shorter time to reporting their date of birth and experienced less nausea, vomiting, and mental side-effects.
Conclusions:
- Total intravenous anesthesia with propofol or etomidate is equally manageable.
- Propofol offers advantages in terms of faster and higher quality recovery compared to etomidate.
- Etomidate was associated with more pronounced nausea, vomiting, mental side-effects, and reduced concentration post-recovery.