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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Jun 24, 2026

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
12:55

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

Lung tumor promotion by curcumin.

Stephanie T Dance-Barnes1, Nancy D Kock, Joseph E Moore

  • 1Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

Carcinogenesis
|April 11, 2009
PubMed
Summary
This summary is machine-generated.

Curcumin, tested for cancer prevention, unexpectedly increased lung tumor growth and inflammation in a mouse model. This suggests curcumin may harm smokers and ex-smokers, warranting exclusion from future clinical trials.

Related Experiment Videos

Last Updated: Jun 24, 2026

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
12:55

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

Area of Science:

  • Oncology
  • Chemoprevention
  • Molecular Biology

Background:

  • Curcumin is investigated for anti-inflammatory and antitumor properties, including chemoprevention for colon cancer.
  • Its efficacy as a lung cancer chemopreventive agent requires further investigation, particularly in susceptible populations.

Purpose of the Study:

  • To evaluate the chemopreventive effects of curcumin in a transgenic mouse model of lung cancer.
  • To compare curcumin's effects with known lung tumor promoters and chemopreventive agents.

Main Methods:

  • A doxycycline-inducible, lung-specific Ki-ras(G12C) transgenic mouse model was utilized.
  • Mice were treated with dietary curcumin, butylated hydroxytoluene (BHT), or sulindac following tumor induction.
  • Tumor multiplicity, lesion progression, inflammation, and oxidative damage were assessed.

Main Results:

  • Dietary curcumin significantly increased lung tumor multiplicity and progression to advanced lesions.
  • Curcumin treatment led to increased inflammation and a higher percentage of adenomas and adenocarcinomas.
  • Oxidative damage, indicated by carbonyl protein formation, was significantly elevated in curcumin-treated mice.

Conclusions:

  • Curcumin may promote lung cancer progression and inflammation in a specific organ context.
  • The findings suggest curcumin could enhance reactive oxygen species formation in lung epithelium, potentially harming smokers and ex-smokers.
  • Smokers and ex-smokers should be excluded from ongoing clinical trials investigating curcumin's chemopreventive potential.