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Updated: Jun 24, 2026
08:31
Candida albicans Biofilm Development on Medically-relevant Foreign Bodies in a Mouse Subcutaneous Model Followed by Bioluminescence Imaging
Published on: January 27, 2015
Endogenous Candida albicans infection causing subretinal abscess.
Toshikatsu Kaburaki1, Mitsuko Takamoto, Fumiyuki Araki
1Department of Ophthalmology, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. kabutosi-tky@umin.ac.jp
International Ophthalmology
|April 11, 2009
Summary
A liver transplant patient developed Candida albicans endophthalmitis with a rare subretinal abscess. This case highlights Candida as a potential cause of subretinal abscesses in immunocompromised organ transplant recipients.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Transplantation Medicine
Background:
- Liver transplantation is associated with increased risk of opportunistic infections.
- Endophthalmitis, an inflammation of the eye's interior, can lead to vision loss.
Observation:
- A liver transplant recipient presented with severe eye pain and inflammation.
- Clinical examination revealed anterior chamber inflammation with hypopyon and a subretinal mass.
- The patient had undergone liver transplantation for hepatitis C-related cirrhosis.
Findings:
- Histopathological analysis of vitreous samples confirmed Candida albicans as the causative agent.
- The infection progressed despite systemic and topical antibiotic treatment.
- The patient required multiple pars plana vitrectomy procedures.
Implications:
- Subretinal abscesses, though rare, can be caused by Candida species in endophthalmitis.
- Organ transplant recipients with endophthalmitis should be evaluated for Candida infection.
- This case expands the spectrum of pathogens causing subretinal abscesses.
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