Related Experiment Videos
[Colchicine intoxication in four elderly patients: how to prevent it?]
M-L Le Bellec1, B de la Gastine, B Mosquet
1Centre régional de pharmacovigilance, CHU Côte-de-Nacre, avenue de la Côte-de-Nacre, BP 95182, 14033 Caen cedex 9, France.
Introduction:
In France, unlike other countries, the use of colchicine is preferred to other anti-inflammatory drugs for the treatment of gout.
Case Reports:
We report a case series of four elderly patients (range from 72 to 83 years of age) who presented with colchicine intoxication, all notified to the Basse-Normandie pharmacovigilance centre in 2007. For each patient, one or more risk factors were identified: renal failure, high initial dosage, absence of laboratory monitoring.
Conclusion:
It would be useful to establish specific guidelines for colchicine use in the elderly population.
Related Concept Videos
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Drugs that Destabilize Microtubules
Drug Dosing: Geriatric Patients
Prevention of Further Absorption of Poison
Pharmaceutical Poisoning: Treatment Strategies
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism