[Peripheral neuropathy with hypervitaminosis B6 caused by self-medication]

Area of Science:

• Neurology
• Toxicology
• Nutritional Science

Background:

• Vitamin B6 (pyridoxine) is a common nutrient found in many over-the-counter (OTC) medications and dietary supplements.
• While essential, excessive intake of vitamin B6 can lead to adverse health effects, including neurological complications.

Observation:

• A 92-year-old female presented with significant gait disturbances and diagnosed peripheral neuropathy.
• Investigations revealed elevated blood vitamin B6 levels, indicating hypervitaminosis B6.
• The patient's condition was linked to the self-administration of an OTC drug containing vitamin B6.

Findings:

• Discontinuation of the vitamin B6-containing OTC drug resulted in a decrease in serum vitamin B6 levels.
• The patient experienced notable improvement in gait and neurological deficits after reducing vitamin B6 intake.
• This case highlights the potential for OTC vitamin supplements to cause toxicity.

Implications:

• Hypervitaminosis B6 is a potential, albeit uncommon, cause of peripheral neuropathy.
• Clinicians should consider vitamin B6 toxicity in patients presenting with unexplained neurological symptoms, especially those using OTC supplements.
• Patient education regarding the risks of excessive vitamin B6 intake from self-administered supplements is crucial.