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[Pertussis: data collection and vaccinal strategy]
I Bonmarin1, L Bouraoui, N Guiso
1Département des maladies infectieuses, institut de veille sanitaire, 12, rue du Val-d'Osne, 94415 Saint-Maurice, France. i.bonmarin@invs.sante.fr
Insights
Renacoq surveillance data showed pertussis burden in infants. While data supported adolescent boosters, it did not impact whole-cell vaccine cessation or acellular vaccine introduction effectiveness.
Area of Science:
- Pediatric infectious disease surveillance
- Vaccinology
- Public health policy
Context:
- Renacoq is a French pediatric hospital-based surveillance network established in 1996.
- Monitors pertussis trends and vaccination impact in children.
- Data collection spans from 1996 to 2007, analyzing interactions with vaccine policy changes.
Purpose:
- To study the link between pertussis surveillance data collection and public health policy in France.
- To assess the impact of vaccination strategies on pertussis trends among children.
- To highlight the role of hospital practitioners in public healthcare surveillance.
Summary:
- Microbiologists and pediatricians collected pertussis diagnoses and case data from children under 16.
- Positive cultures were validated by a national reference laboratory.
- Analysis focused on the period 1996-2007 and its relation to pertussis vaccine policy shifts.
Impact:
- Renacoq data supported adolescent and adult pertussis booster introductions, though impact was moderate due to coverage.
- Data did not support discontinuing whole-cell vaccines or show impact from acellular vaccine introduction.
- The study underscores the disease burden in infants and the importance of surveillance data for public health decisions.
Unlabelled:
Renacoq is a pediatric hospital-based surveillance network in France, set up in April 1996 to monitor the trend of pertussis among children and the impact of vaccination strategies.
Method:
The authors studied the link between data collection and public health policy. Microbiologists from 43 hospitals notify diagnosis of pertussis among children less than 16 years of age. Pediatricians complete a questionnaire for infants less than 6 months of age fulfilling the case definitions. Positive cultures are sent to the National reference laboratory to validate biological results. Data collected from 1996 to 2007 was analyzed, as well as its interaction with changes in pertussis vaccine policy.
Results:
The introduction of adolescent and adult boosters was largely supported by Renacoq data but this was not the case for interruption of whole cell vaccine use. The impact of adolescent booster is moderate because of a limited vaccine coverage. There was no observed impact of the adult booster but the coverage is very weak. The introduction and then the sole use of acellular vaccine did not have any impact on Renacoq data.
Discussion:
The study illustrates the burden of the disease among infants and the link between surveillance data collection and public health decision. It highlights the difficulty to implement new vaccine strategies and the importance of data collection, stressing the need for a better consideration of hospital practitioners involved in public healthcare surveillance.
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