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Updated: Jun 24, 2026
06:54
A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
Published on: June 22, 2022
Mechanisms and targets for angiogenic therapy after stroke
Deepti Navaratna1, Shuzhen Guo, Ken Arai
1Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA. navaratna.deepti@mgh.harvard.edu
Cell Adhesion & Migration
|April 14, 2009
Summary
Enhancing blood vessel formation (angiogenesis) after stroke may improve recovery. Research explores growth factors, cells, and their interaction with new neuron growth (neurogenesis) for novel stroke therapies.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Vascular Biology
Background:
- Stroke is a leading cause of long-term disability worldwide.
- Current treatments for stroke recovery are limited.
- Enhancing angiogenesis after focal cerebral ischemia shows promise for improving outcomes.
Purpose of the Study:
- To review emerging mechanisms and potential targets for angiogenic therapies in the brain after stroke.
- To explore the interplay between angiogenesis and neurogenesis in stroke recovery.
Main Methods:
- Literature review of recent findings on angiogenesis and neurogenesis in stroke.
- Survey of molecular mechanisms and potential therapeutic targets.
Main Results:
- Angiogenesis strategies may offer unique opportunities for stroke recovery.
- Multiple elements like growth factors, adhesion molecules, and progenitor cells are involved.
- Cross-talk between angiogenesis and neurogenesis contributes to brain plasticity and remodeling.
Conclusions:
- A deeper understanding of the molecular interplay in these pathways is crucial.
- Novel therapeutic avenues for stroke treatment may emerge from this research.
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