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Updated: Jun 24, 2026

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
Published on: March 22, 2022
What makes general practitioners order blood tests for patients with unexplained complaints? A cross-sectional study
Hèlen Koch1, Marloes A van Bokhoven, Gerben ter Riet
1Division of Clinical Methods and Public Health, Department of General Practice, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands. h.koch@amc.uva.nl
Background:
Approximately 13% of consultations in general practice involve patients with unexplained complaints (UCs). These consultations often end with general practitioners (GPs) ordering blood tests of questionable diagnostic informativeness.
Objective:
We studied factors potentially associated with GPs' decisions to order blood tests.
Methods:
Cross-sectional study. Twenty-seven GPs completed registration forms after each consultation concerning newly presented UCs.
Results:
Of the 100 analysable patients, 59 had at least one blood test ordered. The median number of ordered tests was 10 (interpercentile range [IPR-90] 2-15). Compared to abdominal complaints, the blood test ordering (BTO) probability for fatigue was five times higher (relative risk [RR] 5.2). Duration of complaints for over 4 weeks also increased this probability (RR 1.6). Factors associated with a lower BTO probability were: likelihood of background psychosocial factors (RR 0.4) and GPs having a syndrome rather than symptom type of working hypothesis (RR 0.5).
Conclusion:
We found a high rate of BTO among GPs confronted with patients with UCs. Furthermore, a considerable number of tests were ordered. The selectivity in BTO behaviour of GPs can be improved upon.
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