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Related Concept Videos

One-Compartment Model: IV Infusion01:09

One-Compartment Model: IV Infusion

Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
Two-Compartment Open Model: IV Infusion01:15

Two-Compartment Open Model: IV Infusion

A two-compartment model is a vital tool in pharmacokinetics, providing an essential understanding of drug behavior, especially for those administered via zero-order intravenous infusion. This model outlines two compartments: the central compartment, where elimination occurs, and the peripheral compartment.
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...

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Related Experiment Video

Updated: Jun 24, 2026

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
09:38

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

Isolated limb infusion: a review.

Hidde M Kroon1, John F Thompson

  • 1Sydney Melanoma Unit, Melanoma Institute Australia, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. hmkroon@hotmail.com

Journal of Surgical Oncology
|April 15, 2009
PubMed
Summary
This summary is machine-generated.

Isolated limb infusion offers a less invasive alternative to isolated limb perfusion for advanced limb melanoma and sarcoma. This simpler technique shows comparable efficacy, potentially becoming the preferred treatment for these conditions.

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Last Updated: Jun 24, 2026

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
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Published on: January 31, 2025

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A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Technology

Background:

  • Isolated limb perfusion (ILP) is the standard treatment for locally advanced melanoma and sarcoma in the limbs.
  • ILP achieves high response rates and durable responses but is invasive and complex.
  • Minimally invasive alternatives are sought to improve patient outcomes and procedural simplicity.

Purpose of the Study:

  • To evaluate isolated limb infusion (ILI) as a minimally invasive alternative to ILP.
  • To compare the efficacy and safety of ILI with ILP for limb malignancies.
  • To determine the potential of ILI to replace ILP in clinical practice.

Main Methods:

  • Review of treatment outcomes from multiple international centers reporting on ILI procedures.
  • Analysis of response rates and duration of response for melanoma and sarcoma treated with ILI.
  • Comparison of ILI outcomes with historical data from ILP for similar patient populations.

Main Results:

  • ILI demonstrates comparable response rates to ILP for both melanoma and sarcoma.
  • The procedure is reported as simpler and less invasive than ILP.
  • No significant differences in response duration were noted between ILI and ILP.

Conclusions:

  • Isolated limb infusion is a viable, minimally invasive alternative to isolated limb perfusion.
  • ILI offers comparable efficacy to ILP for advanced limb melanoma and sarcoma.
  • ILI may become the future standard of care for these conditions due to its simplicity and effectiveness.