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Updated: Jun 24, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Novel drug-loaded gelatin films and their sustained-release performance
Mei Lin1, Sheng Meng, Wei Zhong
1Department of Macromolecular Science, Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, Fudan University, Shanghai 200433, China.
Abstract:
A new particulate drug delivery system with gelatin matrix containing Ibuprofen as a model drug molecule was developed for an epidermis drug prolonged release. Gelatin films containing Ibuprofen-loaded poly-epsilon-caprolactone (PCL) microspheres have been developed on evaporation of organic solvent from an oil-in-water emulsion followed by cross-linking. The microspheres were characterized for particle size, encapsulation efficiency, and surface morphology. Water uptake, matrix erosion, and drug release profile of the microsphere-film system were investigated. The results indicated that drug-loaded microspheres introduced in this system successfully prolonged drug release time. This kind of microsphere-film system combined good adhesion, typical for gelatin films, with the sustained release performance of PCL microspheres.
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