Related Experiment Video
Updated: Jun 24, 2026
Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
A feasibility study on the use of digital tomosynthesis with individually-acquired megavoltage portal images for
V Sarkar1, C Shi, P Rassiah-Szegedi
1Cancer Therapy and Research Center, University of Texas Health Science Center, San Antonio, TX, USA. sarkar@uthscsa.edu
Purpose:
To determine the feasibility of using megavoltage (MV) images and digital tomosynthesis to determine the three dimensional (3D) localization of different objects.
Materials And Methods:
Different phantom geometries were imaged using an electronic portal imaging device and digital tomosynthesis was used to reconstruct tomograms. These were compared with corresponding computed tomography (CT) images.
Results:
While in-plane resolution of the tomograms was comparable as that of the CT images, definite out-of-plane (depth) localization was restricted to 5 mm.
Conclusion:
The results confirm that it is possible to perform 3D localization of objects by using digital tomosynthesis for volumetric reconstructions from individually-acquired MV-quality portal images.
