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Protective effect of vitamin A on ARA-C induced intestinal damage in mice
Murat Elli1, Oguz Aydin, Sirri Bilge
1Department of Pediatric Oncology, Medical Faculty, Ondokuz Mayis University, Samsun, Turkey. ellimurat@yahoo.com
Background:
Cytarabine (ARA-C) has been used for many years in the treatment of patients with leukemia and lymphoma. Gastrointestinal ulceration and mucositis are two of the well-known side effects of ARA-C. We set out to investigate whether vitamin A (VA) can help prevent ARA-C-induced mucosal lesions in mice.
Materials And Methods:
Mice were divided into 5 groups. Group I (control group) received only saline; group II received ARA-C plus saline; group III received ARA-C plus VA; group IV received ARA-C plus a lipid solution, and group V received VA alone. VA (5000 IU/kg) was administered orally to the mice once daily for 7 days. ARA-C (3.6 mg) was administered intraperitoneally for 5 days to groups II, III and IV, starting on the third day of VA treatment. Intestinal segments from the proximal end of the jejunum of treated mice were isolated.
Results:
There was improved mucosal integrity, less necrosis and increased villus length with advanced mucosal proliferation in crypts in the VA plus ARA-C group when compared to the ARA-C groups without VA.
Conclusion:
We conclude that VA has a protective effect against ARA-C-induced mucosal damage in mice.
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