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Causal link between oxidative stress, inflammation, and hypertension
1Department of Medicine, University of California, Irvine, California, USA. ndvaziri@uci.edu
Iranian Journal of Kidney Diseases
|April 16, 2009
Summary
Hypertension (HTN) involves a harmful cycle of oxidative stress and inflammation, damaging organs. Interrupting this cycle is key to managing HTN and its complications.
Area of Science:
- Cardiovascular Medicine
- Pathophysiology
Background:
- Hypertension (HTN) is a significant risk factor for severe cardiovascular and renal diseases.
- Oxidative stress and inflammation are integral to the development and progression of HTN and its complications.
Purpose of the Study:
- To review the role of oxidative stress and inflammation in HTN pathogenesis.
- To examine HTN's contribution to oxidative stress and inflammation.
- To discuss the tissue angiotensin system's role and treatment strategies for HTN-associated oxidative stress.
Main Methods:
- Literature review of existing evidence.
- Analysis of the interplay between HTN, oxidative stress, and inflammation.
- Examination of the tissue angiotensin system's involvement.
Main Results:
- Evidence supports a self-perpetuating cycle involving HTN, oxidative stress, and inflammation.
- This cycle leads to progressive target organ damage.
- The tissue angiotensin system plays a role in this cycle.
Conclusions:
- Oxidative stress and inflammation are critical in HTN pathogenesis and complications.
- Targeting this cycle, including the tissue angiotensin system, is a potential therapeutic approach.
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