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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Bulimia Nervosa01:30

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
Binge Eating Disorders01:23

Binge Eating Disorders

Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...

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Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Multidisciplinary approach to obesity.

L M Donini1, M L Donini, C Savina

  • 1Department of Medical Physiopathology (Food Science Laboratory), University of Rome La Sapienza, 00185 Rome, Italy. lorenzomaria.donini@uniroma1.it

Eating and Weight Disorders : EWD
|April 16, 2009
PubMed
Summary
This summary is machine-generated.

An integrated obesity treatment combining nutrition, physical activity, and behavioral therapy significantly improves weight loss and quality of life. This multidimensional approach (Nutritional Psycho-Physical Reconditioning - NPPR) is more effective than standard dietetic treatment alone.

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Area of Science:

  • Obesity research
  • Metabolic disorders
  • Behavioral medicine

Background:

  • Obesity is a complex disorder linked to significant morbidity and mortality.
  • Current treatments often lack long-term efficacy.
  • An integrated approach involving nutrition, physical activity, and psychotherapy is recommended but its feasibility and effectiveness are debated.

Purpose of the Study:

  • To evaluate the effectiveness of a multidimensional approach, Nutritional Psycho-Physical Reconditioning (NPPR), for obesity treatment.
  • To compare NPPR with standard dietetic treatment.

Main Methods:

  • A study included 464 adult patients (18-65 years) with a BMI >30 kg/m2.
  • Patients were assigned to either standard dietetic treatment (N) or the integrated NPPR program.
  • The NPPR program included nutritional intervention, physical reconditioning, and cognitive-behavioral psychotherapy.

Main Results:

  • The NPPR group showed significantly longer treatment duration and lower dropout rates (5.5% vs 54.4%).
  • Greater weight loss and reduction in fat mass were observed in the NPPR group.
  • NPPR participants demonstrated improved physical function (6-minute walk test, muscular strength) and enhanced psychological well-being (mood, anxiety, quality of life).

Conclusions:

  • An integrated, multidimensional approach (NPPR) is effective for obesity treatment.
  • This approach yields significant short-term improvements in weight, physical function, and psychological health.
  • NPPR represents a promising strategy for managing obesity effectively.