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Published on: February 14, 2017
Coagulation and fibrinolysis in thyroid dysfunction.
1Department of Internal Medicine, Karadeniz Technical University, Trabzon, Turkey. cihangirerem@hotmail.com
Endocrine
|April 16, 2009
Summary
Thyroid dysfunction can cause bleeding or clotting issues due to hormone effects on hemostasis. Hyperthyroidism often means increased clotting, while hypothyroidism
Area of Science:
- Endocrinology
- Hematology
- Internal Medicine
Background:
- Thyroid diseases are linked to diverse hemostasis abnormalities, from mild lab changes to severe bleeding or clotting.
- These hemostatic issues can manifest as clinical disorders, major hemorrhage, or thromboembolism.
Purpose of the Study:
- To review the intricate relationships between thyroid dysfunction and hemostasis.
- To explore impacts on primary hemostasis and the coagulation/fibrinolytic system.
Main Methods:
- Literature review of recent studies on thyroid dysfunction and hemostasis.
- Analysis of direct effects of thyroid hormones on hemostatic parameters.
- Consideration of thyroid autoimmunity's role in hemostasis.
Main Results:
- Thyroid dysfunction significantly impacts hemostasis, primarily through direct thyroid hormone effects on synthesis.
- Hyperthyroidism is associated with hypercoagulability and hypofibrinolysis.
- Hypothyroidism's hemostatic profile varies with disease severity; subclinical disease requires further investigation.
Conclusions:
- Thyroid hormones directly influence various hemostatic parameters.
- Thyroid autoimmunity can alter primary and secondary hemostasis.
- Further research is essential for understanding hemostasis in subclinical thyroid disease.
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