Related Experiment Video
Updated: Jun 24, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Mirizzi's syndrome: a diagnostic dilemma
I N Masih1, R J Moorehead, G R Caddy
1Department of Gastroenterology, Ulster Hospital, Belfast, UK. izhaq@doctors.net.uk
Mirizzi syndrome, caused by gallstones compressing the common bile duct, can be difficult to diagnose definitively. Surgical exploration is often necessary to confirm the condition and differentiate it from other biliary strictures.
Area of Science:
- Gastroenterology
- Hepatobiliary Surgery
Background:
- Gallstones are common, but can lead to complications like biliary obstruction.
- Mirizzi syndrome is a rare complication involving extrinsic compression of the common bile duct by impacted gallstones.
Observation:
- A 62-year-old male presented with abdominal discomfort and was found to have gallstones and biliary dilatation.
- Imaging revealed a common bile duct stricture, initially suspected to be intrinsic.
- Laparotomy identified a large gallstone causing extrinsic compression, characteristic of Mirizzi syndrome.
Findings:
- The study highlights a case of Mirizzi syndrome presenting as a common bile duct stricture.
- Diagnosis was challenging, requiring surgical exploration to identify the extrinsic compression by a gallstone.
- Post-surgical intervention, repeat ERCP showed resolution of the stricture, underscoring the diagnostic dilemma.
Implications:
- Clinicians must consider Mirizzi syndrome in cases of unexplained biliary strictures, especially with a history of gallstones.
- Definitive diagnosis often necessitates surgical exploration due to limitations of non-invasive imaging and ERCP.
- Awareness of this condition can improve diagnostic accuracy and patient management in hepatobiliary disease.
Related Concept Videos
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Myasthenia Gravis: Diagnostic Tests
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Myocarditis II: Clinical Features and Diagnostic Tests