[The influence of mexidol on post-radiation recovery of hemopoietic system]

The purpose of this work was the study in experiments on mice of influence of mexidol on current and outcome of an acute radiation sickness. At an irradiation in a dose 6.0 Gy was studied a condition of hemopoietic system, and at an irradiation in a dose 7.7 Gy a survival rate of animals. In all experiments mexidol applied in two circuits of introduction. The first circuit - once per day with 1 for 8 day after the irradiation. The second circuit of introduction: with 1 for 5 day--two times per day and on 6-8 day once per day. The introduction of mexidol after influence of ionizing radiation reduces a degree of radiative defeat of bone marrow and promotes the activization post-radiation recovery of an erythropoiesis, neutrophilopoiesis in an bone marrow and lymphopoiesis in a thymus gland. This effect is more expressed at introduction mexidol two times per day. At influence of ionizing radiation in a dose 7.7 Gy has survived 56% of mice. The introduction of mexidol two times per day was enlarged by survival rate animal up to 94%. The application of mexidol once per day essentially did not influence on the survival rate of the irradiated mice. The received data show, that the introduction of mexidol with 1 for 8 day after an irradiation, frameing a favorable metabolic background, stimulates recovery processes in hemopoietic system, reduces gravity of a acute radiation sickness and by that enlarges the survival rate of the irradiated animals.