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Nephroprotective and clinical potential of statins in dialyzed patients

Jacek Rysz1, Wilbert S Aronow, Robert S Stolarek

  • 1Medical University of Lodz, Department of Nephrology, Hypertension and Family Medicine, Lodz, Poland.

Expert Opinion on Therapeutic Targets
|April 17, 2009
PubMed

Insights

Statins may offer benefits for chronic kidney disease (CKD) patients, but evidence is limited. Physicians should discuss the routine use of these HMG-CoA reductase inhibitors with patients on dialysis.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Dyslipidemia in chronic kidney disease (CKD) contributes to high cardiovascular mortality and vascular complications.
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) inhibitors, commonly known as statins, are being investigated for their potential benefits in managing CKD.

Purpose of the Study:

  • To examine the current evidence regarding the use of statins in patients with chronic kidney disease.

Main Methods:

  • A comprehensive review of existing medical literature was conducted.

Main Results:

  • Clinical trial evidence specifically for CKD patients undergoing maintenance dialysis is currently limited.

Conclusions:

  • The routine prescription of statins for CKD patients on maintenance dialysis is not definitively established.
  • Physicians should engage in shared decision-making with patients regarding statin therapy.
Abstract

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