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Hedgehog Signaling Pathway

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

Hedgehog Signaling Pathway

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

Migration

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Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.

Social Traps

Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned more cows, the larger...

Predator-Prey Interactions

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Predators consume prey for energy. Predators that acquire prey and prey that avoid predation both increase their chances of survival and reproduction (i.e., fitness). Routine predator-prey interactions elicit mutual adaptations that improve predator offenses, such as claws, teeth, and speed, as well as prey defenses, including crypsis, aposematism, and mimicry. Thus, predator-prey interactions resemble an evolutionary arms race.Although predation is commonly associated with carnivory, for...

Habitat Fragmentation

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Habitat fragmentation describes the division of a more extensive, continuous habitat into smaller, discontinuous areas. Human activities such as land conversion, as well as slower geological processes leading to changes in the physical environment, are the two leading causes of habitat fragmentation. The fragmentation process typically follows the same steps: perforation, dissection, fragmentation, shrinkage, and attrition.

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Related Experiment Video

Updated: Jun 24, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

Trafficking, development and hedgehog.

Fiona Simpson¹, Markus C Kerr, Carol Wicking

¹The University of Queensland, Institute for Molecular Bioscience, Qld, Australia.

Mechanisms of Development

|April 17, 2009

Summary

This summary is machine-generated.

Intracellular trafficking networks control embryogenesis by regulating morphogen transport. This review highlights how sonic hedgehog signaling relies on cellular trafficking, including the primary cilium and lipids, for proper development.

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Area of Science:

Developmental Biology
Cell Biology
Molecular Biology

Background:

Embryogenesis relies on signaling pathways and master regulators.
Intracellular trafficking networks provide an additional layer of developmental control.
The morphogen sonic hedgehog (Shh) transport is crucial for morphogenesis.

Purpose of the Study:

To review the regulation of hedgehog signaling by intracellular trafficking.
To highlight the role of the primary cilium and lipids in hedgehog pathway activity.

Main Methods:

Literature review of recent data on intracellular trafficking.
Focus on sonic hedgehog (Shh) transport, secretion, modification, internalization, and signal transduction.
Examination of the primary cilium and lipid involvement.

Main Results:

Intracellular trafficking is critical for controlling morphogenesis and development.
The transport and localization of sonic hedgehog (Shh) are key regulatory steps.
Lipids and the primary cilium play significant roles in mediating hedgehog pathway activity.

Conclusions:

Intracellular trafficking networks are essential regulators of developmental signaling pathways.
Understanding Shh trafficking provides insights into broader developmental mechanisms.
Targeting trafficking pathways could offer new therapeutic strategies for developmental disorders.