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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Increased basal myocardial perfusion in patients with chronic kidney disease without symptomatic coronary artery

Niina Koivuviita1, Risto Tertti, Mikko Järvisalo

  • 1Department of Medicine, Turku University Hospital, Finland. niina.koivuviita@tyks.fi

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|April 17, 2009
PubMed

Insights

Chronic kidney disease (CKD) patients show increased baseline myocardial blood flow and peripheral endothelial dysfunction. Coronary flow reserve remains normal, suggesting distinct vascular mechanisms in CKD.

Area of Science:

  • Cardiovascular research
  • Nephrology
  • Vascular biology

Background:

  • Minor renal dysfunction is a significant cardiovascular risk factor.
  • Vascular abnormalities in chronic kidney disease (CKD) are not fully understood.
  • Investigating early microvascular dysfunction in CKD is crucial.

Purpose of the Study:

  • To determine if microvascular dysfunction, an early indicator of coronary dysfunction, is present in early stages of CKD.
  • To assess coronary and peripheral artery function in CKD patients using positron emission tomography (PET).

Main Methods:

  • Myocardial blood flow measured by PET at rest and during dipyridamole-induced hyperemia.
  • Peripheral artery endothelial function assessed via flow-mediated dilatation (FMD) of the brachial artery.
  • Study included 22 CKD patients and 10 healthy controls, excluding diabetics.

Main Results:

  • CKD patients exhibited significantly higher basal myocardial perfusion compared to controls.
  • A negative correlation was found between baseline myocardial perfusion and estimated glomerular filtration rate.
  • Peripheral endothelial dysfunction (reduced FMD) was observed in all CKD patients, irrespective of disease stage.

Conclusions:

  • Coronary flow reserve was normal in CKD patients, despite increased baseline myocardial blood flow.
  • Peripheral endothelial dysfunction is a consistent finding in CKD patients.
  • Coronary perfusion and peripheral vascular function appear to be affected by different mechanisms in CKD.
Abstract

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