Related Experiment Video
Updated: Jun 23, 2026

Escherichia coli -Based Complementation Assay to Study the Chaperone Function of Heat Shock Protein 70
Published on: March 8, 2024
[The extracellular heat shock protein 70 and its functions]
Abstract:
Various stress factors induce the accumulation of intracellular heat shock proteins, in particular heat shock protein 70 (Hsp70), which is considered as the main component of cellular response to stress. Though initially Hsp70 was thought to be a typical intracellular protein, the strong evidence now exists demonstrating that the Hsp70 exits mammalian cells not only following necrotic cell death but also by a process involving its active release. This review discusses the mechanisms of Hsp70 release and immunomodulatory and signaling functions of extracellular Hsp70.
Related Concept Videos
Other Stress Responses in Bacteria
Bacterial Protein Maturation
Molecular Chaperones and Protein Folding
The...
Molecular Chaperones and Protein Folding
The...
Regulation of the Unfolded Protein Response
Diversity of Archaea IV

