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Updated: Jun 23, 2026

HPLC Coupled with Chemical Fingerprinting for Multi-Pattern Recognition for Identifying the Authenticity of Clematidis Armandii Caulis

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Published on: November 11, 2022

Lactones from Angiopteris caudatiformis.

Yong-Ming Yu¹, Jun-Shan Yang, Chao-Zhong Peng

¹Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.

Journal of Natural Products

|April 18, 2009

Summary

Two novel lactones, Angiopterlactones A and B, were isolated from Angiopteris caudatiformis rhizome. These compounds, along with known lactones, exhibited cytotoxic and insect antifeeding activities.

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Last Updated: Jun 23, 2026

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HPLC Coupled with Chemical Fingerprinting for Multi-Pattern Recognition for Identifying the Authenticity of Clematidis Armandii Caulis

Published on: November 11, 2022

Area of Science:

Natural Product Chemistry
Phytochemistry
Organic Chemistry

Background:

The rhizome of Angiopteris caudatiformis is a potential source of bioactive natural products.
Lactones are a diverse class of organic compounds with various biological activities.

Purpose of the Study:

To isolate and characterize novel and known lactones from Angiopteris caudatiformis rhizome.
To evaluate the biological activities of the isolated compounds, including cytotoxicity and insect antifeeding properties.

Main Methods:

Isolation of compounds using chromatographic techniques.
Structure elucidation of novel compounds using Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS).
Confirmation of structure and absolute configuration using X-ray crystallography, Circular Dichroism (CD) spectroscopy, and modified Mosher's method.

Main Results:

Two new lactones, Angiopterlactones A (1) and B (2), were identified.
Three known lactones, osmundalactone (3), osmundalin (4), and 3,5-dihydroxy-gamma-caprolactone (5), were also isolated.
Compound 1 showed slight cytotoxicity against HeLa cells (IC(50) = 68.8 microM).
Compounds 3 and 4 exhibited moderate insect antifeeding activity against Plutella xylostella and Heliothis virescens.

Conclusions:

Angiopteris caudatiformis rhizome contains unique lactone structures with potential bioactivity.
Angiopterlactones A and B represent new chemical entities with potential for further investigation.
The isolated compounds demonstrate potential applications in medicine (cytotoxicity) and agriculture (insect control).