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Kinetics of self-immolation: faster signal relay over a longer linear distance?
Ho Yong Lee1, Xuan Jiang, Dongwhan Lee
1Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, USA.
Organic Letters
|April 18, 2009
Abstract:
A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient "shortcut" that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.
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