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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
Changes in prostate-specific antigen levels and prostate volume in octogenarian men: community-based study
Jae Seung Chung1, Seok-Soo Byun, Byung Kyu Han
1Department of Urology, Pochon Cha University College of Medicine, Seongnam, Korea.
Urology
|April 18, 2009
Summary
Prostate volume increased in octogenarian men, but serum prostate-specific antigen (PSA) levels did not significantly differ from septuagenarians. PSA remains a reliable marker for prostate volume in older men.
Area of Science:
- Gerontology
- Urology
- Biomarkers
Background:
- Prostate-specific antigen (PSA) and prostate volume (PV) are key indicators in male urological health.
- Understanding age-related changes in these parameters is crucial for geriatric care.
Purpose of the Study:
- To compare PSA levels and PV in octogenarian men versus septuagenarian men.
- To assess the utility of PSA as a surrogate marker for PV in octogenarians.
Main Methods:
- Analysis of 441 Korean men aged 70-89 from a prospective cohort study.
- PV measured via transrectal ultrasonography; PSA levels determined by immunoradioassay.
Main Results:
- No significant difference in serum PSA levels between 70s and 80s age groups (P = .128).
- Men in their 80s exhibited greater total and transitional PV (P = .026, P = .009).
- PV and PSA correlated with age (P = .034); increased PV stratified by PSA was significant (P < .0001).
Conclusions:
- Despite increasing PV in octogenarians, PSA levels did not significantly differ from septuagenarians.
- PSA is proposed as a reliable surrogate marker for PV, even in the oldest-old men.
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