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Published on: October 6, 2022
Treatment interruption in chronic HIV-1 infection: does it deliver?
Christian B Willberg1, Douglas F Nixon
1Division of Experimental Medicine, University of California San Francisco, San Francisco, California 94110, USA.
Purpose Of Review:
This review sets out to overview treatment interruption in chronic HIV-1 infection: what treatment interruption promised, results from recent trials, and what the future holds.
Recent Findings:
Recent studies have produced mixed results; several trials have been prematurely halted, whereas others have reported more positive outcomes. One consistent finding has been the identification of the CD4 T-cell count nadir as a critical parameter in determining the outcome of treatment interruption.
Summary:
The use of treatment interruption is still controversial, but it is becoming clear that certain individuals could benefit, and partial treatment interruption strategies warrant further investigation.
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