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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
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Cell-mediated Immune Responses

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Related Experiment Video

Updated: Jun 23, 2026

Murine Full-thickness Skin Transplantation
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Intestinal transplantation: evolution in immunosuppression protocols.

Jacques Pirenne1, Masaru Kawai

  • 1Abdominal Transplant Surgery, University Hospitals Leuven, Herestraat 49, Leuven B-3000, Belgium. jacques.pirenne@uzleuven.be

Current Opinion in Organ Transplantation
|April 18, 2009
PubMed
Summary

Intestinal transplantation, once considered a forbidden procedure, has improved outcomes due to advancements in immunosuppression and patient care. However, survival rates for intestinal transplants have plateaued, necessitating new strategies for graft acceptance.

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Area of Science:

  • Gastroenterology
  • Transplantation Immunology
  • Surgical Innovation

Background:

  • Intestinal transplantation is a critical treatment for short bowel syndrome (SBS) with severe complications.
  • Historically, intestinal transplantation faced significant challenges due to high rates of rejection and sepsis.
  • The intestine was often considered a 'forbidden' organ for transplantation.

Observation:

  • Improved outcomes are linked to tacrolimus-based immunosuppression and induction therapy.
  • Better control of cytomegalovirus (CMV) and post-transplant lymphoproliferative disorder (PTLD) with ganciclovir and rituximab has been crucial.
  • Distinguishing rejection from infection/ischemia and enhanced patient follow-up are key factors.

Findings:

  • Center experience significantly impacts outcomes, more so than specific immunosuppressive protocols.
  • While newer agents like M-TOR inhibitors and infliximab are used, mycophenolate mofetil is less common due to toxicity.
  • No substantial improvement in short-term or long-term survival has been observed since 2000 and 1985, respectively.

Implications:

  • Intestinal transplantation remains a complex immunological challenge, offering a life-saving option for SBS patients.
  • Further advancements are required to make intestinal transplantation a 'quality of life-improving' procedure.
  • Developing strategies to enhance graft acceptance and reduce immunosuppression is essential for future progress.