Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of primary care in response to the global liver disease syndemic: a Lancet Gastroenterology & Hepatology Commission.

The lancet. Gastroenterology & hepatology·2026
Same author

The effect of large differences between cycloplegic and dry refraction on myopic Laser surgery outcomes.

European journal of ophthalmology·2026
Same author

The Influence of Breastfeeding on PRK Outcomes: A Comparison of Visual and Refractive Results.

European journal of ophthalmology·2026
Same author

Long-term rheumatologic comorbidities in familial Mediterranean fever.

Seminars in arthritis and rheumatism·2026
Same author

What is the prevalence of depression and anxiety in externally and internally displaced Ukrainian refugees? A European mixed-methods study.

BMC public health·2026
Same author

Fibromyalgia and Risk of Alzheimer's DiseaseRelated Dementia: A Nationwide Bidirectional Case-Control Study.

Geriatrics (Basel, Switzerland)·2026
Same journal

Utilization of Spectral-Domain Optical Coherence Tomography Based Novel Staging and Closure Pattern Classification Systems in the Management of Macular Hole: Clinical and Prognostic Implications.

Current eye research·2026
Same journal

Thiol-Disulfide Homeostasis, Serum Superoxide Dismutase, and Ischemia‑Modified Albumin Levels in Retinal Vein Occlusion.

Current eye research·2026
Same journal

Investigating the Source and Impact of Elevated Intraocular Insulin Levels in High Myopia.

Current eye research·2026
Same journal

Current Experimental Methods for Restoration of the Tear Film.

Current eye research·2026
Same journal

Apolipoprotein C3 Promotes Retinal Angiogenesis via the MYC Pathway in Hypoxia.

Current eye research·2026
Same journal

Possible Causal Association Between Thyroid-Related Traits and Diabetic Retinopathy Risk: Evidence From 23 Medication-Taking Traits.

Current eye research·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Statins do not decrease the risk for wet age-related macular degeneration.

Nadia Kaiserman1, Shlomo Vinker, Igor Kaiserman

  • 1Hebrew University Medical School, Jerusalem, Israel. nadia.kaiserman@gmail.com

Current Eye Research
|April 18, 2009
PubMed
Summary
This summary is machine-generated.

This study found that statin use was more common in patients undergoing photodynamic therapy (PDT) for age-related macular degeneration (AMD). However, statins did not reduce the risk of AMD requiring PDT.

Related Experiment Videos

Last Updated: Jun 23, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Public Health

Background:

  • Age-related macular degeneration (AMD) is a leading cause of vision loss in older adults.
  • Photodynamic therapy (PDT) is a common treatment for wet AMD.
  • Statins are widely used to manage hyperlipidemia and cardiovascular disease.

Purpose of the Study:

  • To determine if statin use influences the risk of developing or requiring treatment for wet age-related macular degeneration (AMD) with photodynamic therapy (PDT).

Main Methods:

  • A large cohort study (n=139,894) of individuals over 50 years old in Israel was conducted.
  • Data on PDT procedures for AMD and statin prescriptions were collected between 1999 and 2002.
  • Statistical analyses, including age adjustment and case-control analysis, were performed to assess the association between statin use and PDT for wet AMD.

Main Results:

  • PDT for AMD was more prevalent among statin users compared to non-users (0.27% vs. 0.16%).
  • After adjusting for multiple confounding factors, statin use did not show a significant effect on the risk of undergoing PDT for wet AMD.
  • Case-control analysis revealed similar statin use patterns in patients treated with PDT and matched controls.

Conclusions:

  • The findings do not support a protective role for statins in reducing the incidence of wet AMD requiring photodynamic therapy.
  • Further research may be needed to fully elucidate the relationship between statins and AMD progression.