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Related Concept Videos

Ostomy Care01:24

Ostomy Care

Introduction
An ostomy is a surgical procedure that creates an artificial opening from the intestines to the outside of the body, allowing for the rerouting of effluent. This opening is known as a stoma. A stoma usually protrudes above the skin surface, appearing pink or red, moist, and round, and it lacks nerve sensations.
There are different types of ostomies, including colostomies, ileostomies, and urostomies:
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Unrenewable Cells00:50

Unrenewable Cells

In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of their outer...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Related Experiment Video

Updated: Jun 23, 2026

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings
09:37

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings

Published on: December 4, 2021

The new Start dressing range--Urgotul Start, UrgoCell Start.

Gail Powell1

  • 1Wound Care Service, Bristol Primary Care Trust, Community Health, Knowle Clinic, Broadfield, Knowle, Bristol.

British Journal of Nursing (Mark Allen Publishing)
|April 21, 2009
PubMed
Summary
This summary is machine-generated.

New wound dressings containing Nano-OligoSaccharide Factor (NOSF) help heal chronic wounds. NOSF inhibits matrix metalloproteinase (MMP) activity, promoting faster wound closure and reducing healing times.

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Last Updated: Jun 23, 2026

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings
09:37

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings

Published on: December 4, 2021

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications
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Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

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Area of Science:

  • Wound healing research
  • Biomaterials science
  • Dermatology

Background:

  • Delayed wound healing presents clinical, patient, and economic challenges.
  • The National Health Service faces financial burdens due to prolonged wound care.
  • Matrix metalloproteinases (MMPs) play a role in wound pathophysiology.

Observation:

  • UrgoCell Start and Urgotul Start dressings are novel treatments.
  • These dressings are impregnated with Nano-OligoSaccharide Factor (NOSF).
  • NOSF is a new compound designed to inhibit MMP activity.

Findings:

  • Clinical evidence supports MMP inhibition for wound healing.
  • Multi-center Randomized Controlled Trials demonstrate efficacy.
  • The dressings are clinically proven to 'kick-start' healing in at-risk wounds.

Implications:

  • These dressings offer a new therapeutic option for delayed wound healing.
  • Effective wound management can reduce healthcare costs.
  • Improved healing outcomes benefit both patients and clinicians.