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Related Experiment Video

Updated: Jun 23, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

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Published on: August 21, 2017

Idiopathic hypocomplementemic urticarial vasculitis-linked neuropathy.

Massimiliano Filosto¹, Tiziana Cavallaro, Giorgio Pasolini

¹Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital Spedali Civili, Brescia, Italy.

Journal of the Neurological Sciences

|April 21, 2009

Summary

Hypocomplementemic urticarial vasculitis (HUV) can cause progressive neuropathy. This case study highlights axonal nerve damage in HUV, suggesting the need for peripheral nerve evaluation in affected patients.

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Area of Science:

Neurology
Immunology
Dermatology

Background:

Hypocomplementemic urticarial vasculitis (HUV) is a rare small-vessel vasculitis.
Typically presents with urticarial skin lesions and potential extracutaneous involvement.
Significant peripheral nerve damage is usually not a feature of HUV.

Observation:

A patient with idiopathic HUV developed progressive multifocal sensory neuropathy.
Symptoms included sensory disturbances suggestive of nerve damage.
Intravenous immunoglobulin treatment provided temporary symptom relief.

Findings:

Sural nerve biopsy revealed asymmetrical, multifocal nerve fiber loss and axon degeneration.
The nerve biopsy findings suggest ischemic damage secondary to vasculitis.
This indicates that axonal neuropathy can be a complication of HUV.

Implications:

Peripheral nerve involvement should be considered in patients with HUV.
Early detection and management of neuropathy may improve patient outcomes.
This case expands the understanding of HUV's potential neurological manifestations.