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Cerebellar rTMS in PSP: a Double-Blind Sham-Controlled Study Using Mobile Health Technology.

Andrea Pilotto1,2, Maria Cristina Rizzetti3, Alberto Lombardi4

  • 1Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.zale Spedali Civili, 1, 25123, Brescia, Italy. pilottoandreae@gmail.com.

Cerebellum (London, England)
|February 5, 2021
PubMed
Summary
This summary is machine-generated.

Repetitive transcranial magnetic stimulation (rTMS) improved postural stability in progressive supranuclear palsy (PSP) patients. This non-invasive brain stimulation technique offers a promising avenue for managing balance deficits in PSP.

Keywords:
Mobile health technologyPostural instabilityProgressive supranuclear palsyRepetitive transcranial magnetic stimulation

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Area of Science:

  • Neurology
  • Neuroscience
  • Rehabilitation Medicine

Background:

  • Progressive supranuclear palsy (PSP) is a neurodegenerative disease with no effective treatments.
  • Postural instability is a primary symptom significantly impacting patient mobility and quality of life.

Purpose of the Study:

  • To evaluate the efficacy of cerebellar theta burst repetitive transcranial magnetic stimulation (rTMS) in improving postural instability in PSP patients.
  • To assess the impact of rTMS on balance using instrumented measures and mobile digital technology.

Main Methods:

  • A crossover design study involving twenty PSP patients.
  • Patients received either real or sham cerebellar rTMS.
  • Static balance was assessed using a lower back accelerometer in semitandem and tandem positions before and after stimulation.

Main Results:

  • Active rTMS significantly increased the time without falls in both tandem and semitandem tasks (p=0.04).
  • Instrumented analysis showed significant improvements in sway area, velocity, acceleration, and jerkiness with real rTMS compared to sham (p<0.008).

Conclusions:

  • Cerebellar rTMS demonstrated a significant positive effect on postural stability in PSP patients.
  • Mobile digital technology effectively assessed these improvements in a double-blind manner.
  • These findings support further investigation into non-invasive brain stimulation for PSP management.