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Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

Cellular pathology of mitral valve prolapse

Marco Prunotto1, Philippe Primo Caimmi, Massimo Bongiovanni

  • 1Pathology and Immunology Department, University of Geneva, Geneva, Switzerland. marco.prunotto@gmail.com

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|April 21, 2009
PubMed
Abstract

Insights

Mitral valve prolapse (MVP) involves key microscopic changes in the valve fibrosa. Proteoglycans and valvular interstitial cells contribute to MVP, transforming fibroblasts into myofibroblasts.

Area of Science:

  • Cardiovascular Biology
  • Cellular Biology
  • Pathology

Background:

  • Mitral valve prolapse (MVP) is the leading cause of chronic mitral regurgitation, affecting over 144 million people globally.
  • This review examines the structural and cellular aspects of human MVP.
  • The fibrosa layer is critical for valve integrity and shows key microscopic changes in MVP.

Purpose of the Study:

  • To review the structural and cellular mechanisms underlying mitral valve prolapse (MVP).
  • To highlight the role of proteoglycans and valvular interstitial cells in MVP.
  • To understand the cellular transformation from fibroblasts to myofibroblasts in MVP.

Main Methods:

  • Review of existing literature on mitral valve prolapse.
  • Focus on microscopic and cellular changes in human MVP.
  • Analysis of the role of proteoglycans and valvular interstitial cells.

Main Results:

  • The fibrosa layer's structural integrity is compromised in MVP.
  • Proteoglycans and valvular interstitial cells are implicated in MVP initiation and progression.
  • MVP involves the transformation of resting fibroblasts into activated myofibroblasts.

Conclusions:

  • The mitral valve serves as a model for studying early fibroblast transformation into protomyofibroblasts.
  • Understanding cellular changes is crucial for a comprehensive view of MVP beyond mechanics.

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