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Modulation of lysozyme function and degradation after nitration with peroxynitrite

Tiana V Curry-McCoy1, Natalia A Osna, Terrence M Donohue

  • 1Liver Study Unit, Omaha Veterans Affairs Medical Center, USA. tcurrymccoy@unmc.edu

Biochimica Et Biophysica Acta
|April 21, 2009
PubMed
Summary

Peroxynitrite (PN) nitration of lysozyme decreases its activity and increases its degradation by the proteasome. This protein modification by PN is linked to ethanol metabolism and cellular defense mechanisms.

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