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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

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Published on: February 19, 2016

[Bone-targeted ultradeformable nanoliposomes].

Jia Guo¹, Miao Zhang, Yun-feng Li

¹Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences

|April 21, 2009

Summary

Modified ultradeformable nanoliposomes (UL) demonstrate enhanced bone targeting. Ethylenediaminetetramethylene phosphonic acid (EDTMP) modification yielded the most significant bone targeting effect for drug delivery applications.

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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Area of Science:

Nanotechnology and Drug Delivery
Pharmacokinetics and Biodistribution
Materials Science

Context:

Ultradeformable nanoliposomes (UL) are investigated for improved drug delivery.
Modifications using poloxamer 407 (P407), Ethylenediaminetetramethylene phosphonic acid (EDTMP), and 1,12-dodecanediaminetetramethylene phosphonic acid (12-DTMP) were explored.
Pyrene served as a model drug to assess in vivo distribution.

Purpose:

To evaluate the in vivo biodistribution of ultradeformable nanoliposomes (UL) after surface modification.
To determine the effect of P407, EDTMP, and 12-DTMP modifications on the bone targeting efficiency of UL.
To compare the targeting capabilities of modified UL formulations.

Summary:

Four types of ULs were prepared: normal (N-UL), and modified with P407 (P-UL), EDTMP (E-UL), and 12-DTMP (12-UL).
All modified ULs exhibited high encapsulation efficiencies (>80%).
Compared to N-UL, P-UL, E-UL, and 12-UL showed significantly increased pyrene concentrations, AUC, and drug targeting efficiencies (DTE) in bone, with E-UL demonstrating the most pronounced effect.

Impact:

Modified ULs, particularly E-UL, exhibit potent bone-targeting capabilities.
These findings suggest potential for enhanced localized drug delivery to bone tissue.
The study provides valuable insights into optimizing nanoliposome formulations for bone-targeted therapies.