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Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates
Published on: December 6, 2017
In vitro selection of protein and peptide libraries using mRNA display
Terry T Takahashi1, Richard W Roberts
1Department of Chemistry, University of Southern California, Los Angeles, CA, USA.
Methods in Molecular Biology (Clifton, N.J.)
|April 21, 2009
Abstract
None:
In vitro genetic approaches are powerful solutions to the protein design problem. mRNA display is an in vitro selection technique enabling the design of peptide and protein ligands ranging from one to over 100 amino acids. Libraries containing more than 10 trillion unique sequences can be synthesized and sieved with exquisite control over binding stringency and specificity.
