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Related Experiment Video

Updated: Jun 23, 2026

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

Umbilical cord blood cells.

Jennifer D Newcomb¹, Alison E Willing, Paul R Sanberg

¹Department of Neurosurgery, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA.

Methods in Molecular Biology (Clifton, N.J.)

|April 21, 2009

Summary

This summary is machine-generated.

Umbilical cord blood (UCB) offers multipotent stem cells for treating various diseases and injuries. These cells, easily collected and stored, show promise in regenerative medicine and cell therapy applications.

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Last Updated: Jun 23, 2026

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

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Published on: September 14, 2017

Isolation of Precursor B-cell Subsets from Umbilical Cord Blood

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Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

Pan-myeloid Differentiation of Human Cord Blood Derived CD34⁺ Hematopoietic Stem and Progenitor Cells

Published on: August 9, 2019

Area of Science:

Regenerative Medicine
Stem Cell Biology
Hematology

Background:

Umbilical cord blood (UCB) contains multipotent stem cells previously discarded.
These cells are antigenically immature and can reconstitute blood lineages, similar to bone marrow.
UCB is increasingly recognized for its clinical treatment potential.

Purpose of the Study:

To highlight the therapeutic potential of UCB.
To present protocols for UCB mononuclear cell isolation and research use.
To explore UCB's applications in various disease and injury models.

Main Methods:

Identification and characterization of the heterogeneous mononuclear cell fraction of UCB.
Transplantation of UCB cells locally and systemically in animal models.
Cryogenic storage of UCB with minimal cell loss upon thawing.

Main Results:

UCB demonstrates broad therapeutic capacity, including cell replacement, protection, and anti-inflammation.
UCB has shown efficacy in animal models of stroke, myocardial infarction, neurodegenerative diseases, and spinal cord injury.
UCB can be obtained non-invasively and stored effectively.

Conclusions:

UCB is a valuable and accessible source of stem cells for therapeutic applications.
Further research and established protocols will advance the clinical use of UCB.
UCB holds significant promise for treating a wide range of diseases and injuries.