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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Metastatic synovial cell sarcoma in two cats.

J M Liptak¹, S J Withrow, D W Macy

¹Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. jliptak@uoguelph.ca

Veterinary and Comparative Oncology

|April 22, 2009

Summary

Metastatic synovial cell sarcoma (SCS) in cats is rare. This study reports two cases of feline SCS with lymph node metastasis, treated with amputation and chemotherapy, with varied outcomes.

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Published on: August 21, 2012

Area of Science:

Veterinary Oncology
Comparative Pathology
Feline Medicine

Background:

Synovial cell sarcoma (SCS) is an uncommon tumor in domestic animals.
Metastasis of feline SCS to regional lymph nodes has not been previously documented.
Understanding SCS behavior in cats is crucial for effective treatment strategies.

Purpose of the Study:

To report the occurrence and clinical management of synovial cell sarcoma with lymph node metastasis in two cats.
To describe the treatment outcomes and survival times for feline SCS.
To highlight the rarity of metastatic SCS in felines.

Main Methods:

Diagnosis of synovial cell sarcoma in two feline patients.
Surgical treatment involving limb amputation.
Adjuvant chemotherapy with doxorubicin administration.
Postoperative monitoring for tumor recurrence and metastasis.

Main Results:

Both cats were diagnosed with synovial cell sarcoma and metastasis to regional lymph nodes.
One cat experienced local tumor recurrence and pulmonary metastases 316 days post-surgery.
The second cat survived 41 days post-surgery without evidence of recurrence or metastasis.
Survival times varied significantly between the two cases.

Conclusions:

Synovial cell sarcoma can metastasize in cats, a previously unreported finding.
Limb amputation and adjuvant doxorubicin chemotherapy were employed as treatment modalities.
Outcomes for feline SCS with metastasis can be variable, necessitating further research.