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Updated: Jun 23, 2026
Murine Prostate Micro-dissection and Surgical Castration
Published on: May 11, 2016
Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and
K U Sorenmo1, M Goldschmidt, F Shofer
1University of Pennsylvania School of Veterinary Medicine, Departments of Clinical Studies and Pathobiology, Philadelphia, PA 19104-6010, USA. karins@vet.upenn.edu
Abstract:
The purpose of this study was to characterize canine prostate cancer using immunohistochemical staining specific for acinar and urothelial/ductal tissue and correlate these results with the dogs' castration status/castration time. Seventy dogs with prostate cancer were included, 71% were castrated and 29% were intact. Compared with an age-matched control population, castrated dogs were at increased risk of prostate cancer, odds ratio 3.9. Immunohistochemical staining was performed on 58 cases. Forty-six of the 58 stained positive for cytokeratin 7 (CK 7) (ductal/urothelial origin) and one of the 58 stained positive for prostate-specific antigen. Dogs with CK 7-positive tumours were younger when castrated than dogs with CK 7-negative tumours, 2 versus 7 years (P = 0.03); dogs castrated at
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