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Updated: Jun 23, 2026
06:09
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
alpha-Melanocyte-stimulating hormone-induced eruptive nevi
Adela R Cardones1, James M Grichnik
1Department of Dermatology, University of Miami Health System, University of Miami Hospital and Clinics/Sylvester Comprehensive Cancer Center, Melanoma Program, 1475 NW 12th Ave, Location D-1, Miami, FL 33136, USA.
Archives of Dermatology
|April 22, 2009
Summary
Synthetic alpha-melanocyte-stimulating hormone (alpha-MSH) peptides may increase melanoma risk. In a patient with a history of melanoma, alpha-MSH triggered new atypical nevi and growth in existing ones.
Area of Science:
- Dermatology
- Oncology
- Endocrinology
Background:
- Investigating synthetic peptides targeting proopiomelanocortin receptors for tanning.
- Exploring potential protective effects of synthetic alpha-melanocyte-stimulating hormone (alpha-MSH) against melanoma.
- Assessing the biological effects of alpha-MSH in patients with dysplastic nevi or prior melanoma.
Observation:
- A patient with melanoma history and dysplastic nevi self-administered synthetic alpha-MSH.
- Observed development of new pigmented nevi with atypical features and darkening/growth of existing nevi.
- Discontinuation of alpha-MSH led to nevi lightening and loss of growth features.
Findings:
- Synthetic alpha-MSH peptides stimulate proliferation of neoplastic melanocytic cells.
- This proliferation occurred in a patient predisposed to melanoma.
Implications:
- Synthetic alpha-MSH may increase melanoma development risk in susceptible individuals.
- Further research is needed to determine the safety and long-term effects of alpha-MSH in high-risk populations.
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