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Linker immobilization of protein and oligonucleotide on indium-tin-oxide for detection of probe-target interactions

Marwan Saoud1, Christophe Blaszykowski, Scott M Ballantyne

  • 1Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3H6.

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|April 22, 2009
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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...