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Updated: Jun 23, 2026

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
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Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions

Published on: January 26, 2024

Inferring protein-protein interactions from multiple protein domain combinations

Simon P Kanaan1, Chengbang Huang, Stefan Wuchty

  • 1Department of Computer Science, University of Notre Dame, Notre Dame, IN, USA.

Methods in Molecular Biology (Clifton, N.J.)
|April 22, 2009
PubMed
Summary

We developed a novel Maximum Specificity Set Cover (MSSC) algorithm to predict protein-protein interactions using domain composition. This method accurately identifies unknown interactions in yeast and fruit flies, outperforming existing approaches.

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