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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Jun 23, 2026

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 5, 2008

Comparative genomic hybridization: microarray design and data interpretation.

Richard Redon¹, Nigel P Carter

¹Wellcome Trust, Sanger Institute, Cambridge, UK.

Methods in Molecular Biology (Clifton, N.J.)

|April 22, 2009

Summary

This summary is machine-generated.

Microarray-based Comparative Genomic Hybridization (array-CGH) offers flexible whole-genome screening for DNA copy number changes. This method aids in analyzing tumor and constitutional DNA with improved accuracy and resolution.

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Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

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Published on: February 21, 2015

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

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Last Updated: Jun 23, 2026

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 5, 2008

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

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Published on: February 21, 2015

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

Area of Science:

Genomics
Molecular Biology
Cancer Research

Background:

Microarray-based Comparative Genomic Hybridization (array-CGH) is a decade-old technique for detecting submicroscopic DNA copy number variations.
Advancements in genome sequencing have enhanced the flexibility and scope of array-CGH.
array-CGH is crucial for analyzing both tumor and constitutional DNA samples.

Purpose of the Study:

To describe alternative strategies for whole-genome screening using array-CGH.
To present methods for high-resolution breakpoint mapping of copy number changes.
To outline tools for accurate analysis of array-CGH experiments.

Main Methods:

Utilizing microarray platforms, including those with large-insert clones.
Adapting methods for diverse microarray platforms (e.g., oligonucleotide arrays).
Implementing advanced analytical tools for genomic data interpretation.

Main Results:

Demonstration of flexible whole-genome screening capabilities.
Achieved high-resolution mapping of DNA copy number alterations.
Provided a framework for accurate array-CGH data analysis.

Conclusions:

array-CGH is a versatile tool for detecting DNA copy number changes.
The described strategies and tools enhance the application of array-CGH in genomic studies.
Methods are adaptable across various microarray platforms for broad applicability.