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Thoracoscopic cell sheet transplantation with a novel device
Masanori Maeda1, Masayuki Yamato, Masato Kanzaki
1Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.
Journal of Tissue Engineering and Regenerative Medicine
|April 22, 2009
Summary
A novel device enables minimally invasive transplantation of cell sheets for regenerative medicine. This technology facilitates cell sheet delivery in endoscopic surgery, expanding applications for internal organ repair.
Area of Science:
- Regenerative Medicine
- Biomaterials Engineering
- Minimally Invasive Surgery
Background:
- Cell sheet transplantation using temperature-responsive surfaces is established for skin and cornea regenerative medicine.
- Fibroblast cell sheets have shown promise in sealing lung air leaks during surgery.
Purpose of the Study:
- To develop and evaluate a novel device for minimally invasive, endoscopic transplantation of cell sheets.
- To assess the feasibility of using the device for cell sheet delivery to internal organs.
Main Methods:
- A computer-aided design (CAD) system was used to design the transplantation device.
- Rapid prototyping with a 3D printer fabricated the device using a clinically approved photopolymer.
- The device was tested for transplanting 24 x 24 mm cell sheets onto porcine lung models via a 12 mm port in a human body model.
Main Results:
- The novel device successfully enabled minimally invasive transplantation of cell sheets onto porcine lung wound sites.
- The device was inserted and utilized effectively through a 12 mm surgical port, demonstrating feasibility for endoscopic procedures.
Conclusions:
- A 3D-printed device facilitates minimally invasive cell sheet transplantation in endoscopic surgery.
- This technology holds potential for broader applications in regenerative medicine for various internal organs.
