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Dynamic 3D culture promotes spontaneous embryonic stem cell differentiation in vitro

Jörg C Gerlach1, Mariah Hout, Josefina Edsbagge

  • 1Department of Surgery and Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh, PA, USA. joerg.gerlach@cellnet.org

Tissue Engineering. Part C, Methods
|April 23, 2009
PubMed

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.