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Updated: Jun 14, 2026

Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems
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Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems

Published on: February 16, 2024

Design and Fabrication of Demountable 3D Microphysiological Systems.

Selina Banerjee1, Ryan Brady1, Lina Abu-Absi1

  • 1Department of Chemical Engineering, Northeastern University, Boston, Massachusetts, USA.

Tissue Engineering. Part C, Methods
|June 13, 2026
PubMed
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We developed low-cost, demountable organ-on-a-chip platforms using a simple cut-and-assemble method. This innovation overcomes imaging and analysis challenges in current organ chip technology, enabling advanced biological studies.

Area of Science:

  • Biotechnology
  • Tissue Engineering
  • Microfluidics

Background:

  • Organ-on-chip technology offers physiological relevance but faces adoption hurdles.
  • Traditional organ chips have limitations in tissue analysis, harvest, and high-resolution imaging.
  • Transitioning from polydimethylsiloxane to thermoplastics addressed manufacturing challenges but introduced new issues.

Purpose of the Study:

  • To present a novel, low-cost, and demountable organ-on-a-chip platform.
  • To overcome limitations in end-point tissue analysis and high-resolution imaging of multilayer organ chips.
  • To enable easier redesign and manufacture of alternative tissue and interface systems.

Main Methods:

  • Fabrication of fluidically sealed but demountable organ chips using a cut-and-assemble method.
Keywords:
Demountable PlatformEndothelialMicrophysiological SystemNeurovascularOrgan-on-ChipiPSC Differentiation

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Microfabricated Platforms for Mechanically Dynamic Cell Culture
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Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation
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Last Updated: Jun 14, 2026

Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems
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Published on: February 16, 2024

Microfabricated Platforms for Mechanically Dynamic Cell Culture
15:21

Microfabricated Platforms for Mechanically Dynamic Cell Culture

Published on: December 26, 2010

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation
09:37

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Published on: May 12, 2008

  • Utilized thermoplastics and avoided cleanroom technologies for accessibility.
  • Demonstrated cell culture capabilities with human aortic smooth muscle cells and iPSC-derived neural cells in GelMA hydrogel.

    • Main Results:

    • Successfully cultured human cells on-chip for up to 27 days.
    • Enabled removal of the 3D culture layer for high-resolution imaging post-immunostaining.
    • Presented the first innervated organ chip with removable layers and a humanized nerve-artery model with 3D hydrogel culture.

    Conclusions:

    • The developed method provides a low-cost, accessible platform for advanced organ-on-a-chip applications.
    • Demountable design facilitates improved tissue analysis and imaging.
    • The platform is suitable for future investigations into cell crosstalk mechanisms in coculture systems.