Related Experiment Video
Updated: Jun 23, 2026

Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery
Published on: September 30, 2021
Multiple-pulse drug delivery systems: setting a new paradigm for infectious disease therapy
Nitin Saigal1, Sanjula Baboota, Alka Ahuja
1Department of Pharmaceutics, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
Background:
Pulsatile drug delivery of actives based on the body's biological rhythms came into sight as a novel and emerging concept in the field of drug delivery. The concept of late has given birth to another field of research worth exploring: multiple-pulse drug delivery.
Objective:
Delivering a drug in multiple pulses has been applied to antibiotics for effective and patient compliant drug delivery. Delivering antibiotics in divided pulses results in better annihilation of microbes, as it prevents them going into a resistant/dormant stage and developing biological tolerance. The concept appears to have potential, and on 16 March 2009 MiddleBrook Pharmaceuticals, Inc. will launch the first of such once-daily product based on their proprietary pulsatile drug delivery technology, PULSYS.
Methods:
This review focuses on the rationale, possible strategies and technologies employed for multiple-pulse delivery, as well as current status and future trends.
Conclusion:
The concept is in its infancy and promises great potential in the fight against microbial resistance; many approved formulations based on similar approaches with new and improved therapeutic paradigms are anticipated in the near future.
Related Concept Videos
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
Modified-Release Drug Delivery Systems: Classification
Modified-Release Drug Delivery Systems: Rate-Programmed I
Modified-Release Drug Delivery Systems: Rate-Programmed II
Modified-Release Drug Delivery Systems: Overview
Oral Drug Delivery Systems: Continuous-Release Systems
