Related Experiment Video
Updated: Jun 23, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Gastrointestinal ischemia related mortality in patients undergoing off- or on-pump coronary artery bypass grafting
Mustafa Emmiler1, Afsin Yaveri, Cevdet Uğur Koçoğullari
1Department of Cardiovascular Surgery, Faculty of Medicine, Kocatepe University, Afyonkarahisar, Turkey. dremmiler@yahoo.com
Insights
Off-pump coronary artery bypass grafting (OPCAB) shows lower gastrointestinal ischemia (GII) related mortality compared to on-pump (ONCAB) surgery. This finding is crucial for reducing postoperative complications in CABG patients.
Area of Science:
- Cardiovascular Surgery
- Gastrointestinal Surgery
- Surgical Outcomes
Background:
- Gastrointestinal ischemia (GII) is a rare but severe complication following coronary artery bypass grafting (CABG).
- Comparing outcomes between off-pump (OPCAB) and on-pump (ONCAB) CABG is essential for patient safety.
- Understanding risk factors for GII post-CABG is critical for improving patient care.
Purpose of the Study:
- To compare the incidence of GII in patients undergoing OPCAB versus ONCAB procedures.
- To evaluate the impact of surgical technique on GII-related morbidity and mortality.
- To identify potential differences in postoperative complications between OPCAB and ONCAB.
Main Methods:
- Retrospective analysis of 2625 adult patients undergoing isolated CABG over six years.
- Patients were divided into two groups: OPCAB (n=658) and ONCAB (n=1967).
- Comparison of GII incidence, morbidity, and mortality rates between the two groups.
Main Results:
- GII occurred in 0.4% of ONCAB patients and 0.2% of OPCAB patients (P=.28).
- GII-related mortality was 0.2% in the ONCAB group versus 0% in the OPCAB group (P<.04).
- Postoperative atrial fibrillation occurred in 100% of ONCAB patients with GII compared to 0% in OPCAB patients with GII (P<.01).
Conclusions:
- OPCAB surgery is associated with lower GII-related mortality compared to ONCAB.
- GII represents a significant cause of morbidity and mortality after CABG.
- The OPCAB technique may offer a safer alternative for selected patients to reduce GII complications.
Objective:
Gastrointestinal ischemia (GII) after heart surgery is a rare but devastating condition. The aim of this study was to compare the occurrence of GII after coronary artery bypass grafting (CABG) performed off-pump (OPCAB) vs on-pump (ONCAB).
Methods:
We retrospectively evaluated 2625 adult patients who underwent isolated coronary artery surgery during a 6-year period. The OPCAB group included 658 patients and the ONCAB group 1967 patients. Patients were evaluated, and GII, morbidity, and mortality in the 2 groups were compared.
Results:
GII developed in 0.4% (7 of 1967) patients in the ONCAB group and in 0.2% (1 of 658) patients in the OPCAB group (P = .28). Mortality rates due to GII were 0.2% (4 of 1967) in the ONCAB group, and no deaths occurred in the OPCAB group (P < .04). Postoperative atrial fibrillation incidence with GII was 100% (7 of 7) in ONCAB group and 0% (0 of 1) in the OPCAB group (P < .01).
Conclusions:
Compared to ONCAB, the OPCAB procedure has lower GII related mortality rates, which is an important cause of morbidity and mortality in the postoperative period of CABG surgery.
Related Concept Videos
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Peripheral Artery Disease V: Postoperative Nursing Management
Acute Coronary Syndrome IV: Interprofessional Care

