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Design issues in dose-finding Phase I trials for combinations of two agents.

Shenghua Kelly Fan1, Alan P Venook, Ying Lu

  • 1Department of Statistics and Biostatistics, California State University, East Bay, Hayward, California, USA.

Journal of Biopharmaceutical Statistics
|April 23, 2009
PubMed
Summary

This study introduces improved strategies for finding the maximum tolerated dose (MTD) in combination cancer therapy. These new methods offer a more efficient and practical approach to identifying optimal drug combinations.

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