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[OCT in acute anterior uveitis].

J P Moreno-Arrones¹, M B Gorroño-Echebarría, M A Teus

¹Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Madrid, España. javier_paz_moreno@hotmail.com

Archivos De La Sociedad Espanola De Oftalmologia

|April 23, 2009

Summary

Acute anterior uveitis (AAU) patients show increased macular volume and superior retinal nerve fiber layer (RNFL) thickness during active episodes. Optical coherence tomography (OCT) confirms these significant changes compared to healthy controls.

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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

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Published on: January 12, 2022

Area of Science:

Ophthalmology
Medical Imaging
Retinal Diseases

Background:

Acute anterior uveitis (AAU) is an inflammatory condition affecting the eye.
Understanding the structural changes associated with AAU is crucial for patient management.
Optical coherence tomography (OCT) is a key imaging modality for retinal assessment.

Purpose of the Study:

To evaluate macular thickening, optic disc status, and retinal nerve fiber layer (RNFL) thickness in patients with active AAU using OCT.
To compare these OCT parameters between patients with AAU and a healthy control group.

Main Methods:

A prospective, cross-sectional, observational study included 27 eyes from 20 patients with active AAU.
A control group comprised 40 healthy eyes from 20 age- and sex-matched volunteers.
All participants underwent OCT scans, including 'fast macular thickness', 'fast optic disc', and 'fast RNFL thickness' protocols. Patients were re-evaluated after one month.

Main Results:

A statistically significant increase in total macular volume was observed in AAU eyes (7.3 ± 0.6 mm³) compared to healthy eyes (7.01 ± 0.3 mm³), with p<0.001.
A statistically significant increase in superior RNFL thickness (Smax/Imax: 1.05 ± 0.1) was found in AAU eyes compared to controls (0.97 ± 0.1), with p<0.02.

Conclusions:

OCT imaging reveals increased macular volume in patients experiencing an acute episode of AAU.
Superior RNFL thickness is also significantly increased in AAU patients during the acute phase compared to controls.