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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
Hansen's disease with HIV: a case of immune reconstitution disease
Dominic Chow1, Leila Okinaka, Scott Souza
1Department of Medicine, John A Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, HI 96813, USA. dominicc@hawaii.edu
Abstract:
Immune reconstitution inflammatory syndrome (IRIS) is an acute symptomatic expression of a latent infection during the recovery of the immune system usually as a response to antiretroviral therapy (ART). Opportunistic infections can trigger IRIS. Hansen's disease is an infection caused by Mycobacterium leprae (M. leprae). There have been a limited number of case reports reporting the presentation of the co-infection of HIV and M. leprae. We report an unique case of IRIS in a patient co-infected with HIV and M. leprae presenting as an exacerbation of his Hansen's Disease where the patient's skin lesions progressed from borderline tuberculoid to lepromatous leprosy following ART administration.
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